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The chemical company DuPont already uses a strain of E. coli that has been genetically engineered to turn corn syrup into trimethylene glycol, a solvent that is used in the production of plastics and antifreeze.

They include ethylene glycol, propylene glycol, trimethylene glycol, mannitol, sorbitol, dextrans, and seminal-plasma proteins.

It forms an addition product with acrylic ester, which on heating loses nitrogen and leaves trimethylene dicarboxylic ester.

A similar behaviour has since been noticed in other trimethylene derivatives, but the fact that bromine, which usually acts so much more readily than hydrobromic acid on unsaturated compounds, should be so inert when hydrobromic acid acts readily is one still needing a satisfactory explanation.

Perkin, junr., in 1883, that ethylene and trimethylene bromides are capable of acting in such a way on sodium acetoacetic ester as to form tri- and tetra-methylene rings.