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The effectiveness of Cambodia’s surveillance system can be credited in part to one man, Dr. Ly Sovann, an apparently unsleeping tropical medicine specialist who runs the Cambodian Center for Disease Control.

“Code Red is not even a hot enough color for this report, ” said Stanford University tropical medicine professor Dr. Michele Barry, who wasn’t part of the study team.

Dr. Nicholas White, a professor of tropical medicine at Mahidol University in Bangkok, described the new paper’s conclusions about emerging malaria resistance as “unequivocal.”

“You can’t stop everything for very long,” said Dr. Christopher A. Sanford, a family physician with a background in public health and tropical medicine.

Initial hubris gave way to frustration as researchers realized that vaccines against malaria would be difficult to produce, says Nicholas White, who studies tropical medicine at Mahidol University in Bangkok.