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Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells.

Only a subset of cells within these tumours has tumorigenic potential3, 4, suggesting a hierarchical organization.

These data are also consistent with previous reports demonstrating that the number of driver mutations in human-derived intestinal organoids is proportional to their tumorigenic capacity and the extent of chromosomal instability17, 18.

To further define the tumorigenic potential of Lgr5-GFP+ cells within each genotype, we performed limiting-dilution transplants of FACS-sorted tumour cells.

Obesity is commonly known to provide a fertile ground for tumorigenic seeds by changing healthy tissue into a tumor-supporting soil.