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"Our study provides the first report on the atomic-level structure of the 3D-DS phenomenon in an antibody light chain's variable region," points out Hirota.

They found that the variable region #4VL can switch between monomeric and tetrameric states.

Somatic mutations within the immunoglobulin variable region were almost exclusively presented by MHC class II. We isolated circulating CD4+ T cells specific for immunoglobulin-derived neoantigens and found these cells could mediate killing of autologous lymphoma cells.

There is also an additional variable region in the Illumina TruSeq adaptors that has been incorporated and shown in green.

González-Candelas and his colleagues used patterns of changes in a highly variable region of the HCV genome to sort the viruses into clades, or branches of a tree that illustrate their evolutionary relationships.