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For example, coronary vasospasm, a condition in which the arteries feeding the heart quite literally spasm and prevent the heart muscle from getting oxygen, often happens early in the morning.

Watching the reaction to the medications can reveal whether the patient has significant degrees of blood-vessel restriction, or what’s known as vasospasm.

She clearly had severe vasospasm, which was most likely causing the pain and the heart attacks, Bairey Merz told her.

A second paper from Parker's group, published last week in the Proceedings of the National Academy of Sciences, suggests that the same integrin-signaling mechanism may contribute to vasospasm, another harmful process associated with TBI.

Vasospasm typically results after a blow to the head causes bleeding in the space between the brain and the thin tissues that surround it.