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“That’s the trademark of vivax malaria,” Mr. Jagoe said.

In July 2018, the Food and Drug Administration approved 300 milligrams of tafenoquine for the radical cure of P. vivax malaria in adults and adolescents 16 years and older.

The investigators recruited 60 children with P. vivax malaria from three sites in Vietnam and one in Colombia.

“This might mean that we can never eradicate P. vivax malaria—unless we manage to get rid of it in the chimp and gorilla populations too,” Culleton says.

But despite these cautions there is hope the drug, together with bed nets and other precautions, will help reduce the amount of vivax malaria in the world.