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However, considering the associated risks, minimizing xenogeneic components is often advisable, signifying the need to improve the efficiency of reprogramming various types of canine cells in dogs without using feeder cells.

The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients.

We further demonstrate that CD4 T cells are stable in inflammatory conditions not only in vitro but also in vivo in a model of xenogeneic graft-versus-host disease.

Human cells must be transplanted into highly immunocompromised mice to escape the powerful xenogeneic immune response that kills human cells in mice.

There is no opportunity to test whether human cells have tumorigenic potential if they are killed by a xenogeneic immune response.