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My physician prescribed allopurinol, but it made my kidneys feel like they were on fire.

The flare-ups sometimes lasted weeks despite flooding my body with as much water as I could hold, popping a daily crystal-busting allopurinol, and following a prescribed, puzzling diet.

It found that patients on Uloric had a 22 percent higher risk of death from any cause and a 34 percent higher risk of heart-related deaths than patients taking allopurinol, a generic alternative.

I discussed this with my internist, who said he could put me on allopurinol or take me off HCTZ.

Treating the animals with allopurinol, an inhibitor of purine metabolism, eased the colitis.