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This was not the feared 226L mutation: The amino acid had changed to a histidine instead of leucine.

Lo and behold, when they switched a glutamine to a leucine at position 226, it no longer bound to the bird receptors, but instead exclusively to those of humans.

So, proteins with a greater leucine content are generally considered better for muscle growth.

Higher levels of PFOA, which predicted coronary microvascular disease, were associated with higher levels of amino acids isoleucine and leucine and higher levels of pro-inflammatory cytokines.

However, they did find that the variant causes a shift from the amino acid proline to leucine, which may interfere with the formation of a helix found in the normal version.