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By engaging the parasympathetic nervous system, the team observed that inflammation could be eased by inhibiting SUMOylation, a cellular process that shapes immune response.

But for many, the sympathetic nervous system is out of balance with the parasympathetic nervous system, which, along with the vagus nerve, works to calm the body.

The pupil's constriction is an indicator of parasympathetic nervous system function.

It’s a “cuddle puddle,” as Darragh calls the evening activity, adding that silliness and laughter activates the parasympathetic nervous system and relieves stress.

"The average heartbeat slows down, and the activity of the parasympathetic nervous system, which plays an important role in controlling the internal organs, increases."