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They found I have a blood disorder called prothrombin gene mutation.

I had barely removed my coat before the doctor started rattling off the things I had tested negative for: antiphospholipid antibodies, lupus anticoagulant, Factor V Leiden, prothrombin gene mutation.

This is a difficult drug to control, and close monitoring of prothrombin times — a measure of how long it takes a person’s blood to clot — is necessary.

Wrong prothrombin time results could cause doctors to prescribe too little or too much warfarin.

Tests showed that she has a prothrombin gene mutation that, with estrogen, is a time bomb.